Gene Set: SCHUHMACHER_MYC_TARGETS_DN

Standard name SCHUHMACHER_MYC_TARGETS_DN
Systematic name M969
Brief description Genes down-regulated in P493-6 cells (Burkitt's lymphoma) induced to express MYC [GeneID=4609].
Full description or abstract The proto-oncogene c-myc (myc) encodes a transcription factor (Myc) that promotes growth, proliferation and apoptosis. Myc has been suggested to induce these effects by induction/repression of downstream genes. Here we report the identification of potential Myc target genes in a human B cell line that grows and proliferates depending on conditional myc expression. Oligonucleotide microarrays were applied to identify downstream genes of Myc at the level of cytoplasmic mRNA. In addition, we identified potential Myc target genes in nuclear run-on experiments by changes in their transcription rate. The identified genes belong to gene classes whose products are involved in amino acid/protein synthesis, lipid metabolism, protein turnover/folding, nucleotide/DNA synthesis, transport, nucleolus function/RNA binding, transcription and splicing, oxidative stress and signal transduction. The identified targets support our current view that myc acts as a master gene for growth control and increases transcription of a large variety of genes.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 11139609   Authors: Schuhmacher M,Kohlhuber F,Hölzel M,Kaiser C,Burtscher H,Jarsch M,Bornkamm GW,Laux G,Polack A,Weidle UH,Eick D
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Organism Homo sapiens
Contributed by Yujin Hoshida (Broad Institute)
Source platform AFFY_HuGene
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