Gene Set: SUH_COEXPRESSED_WITH_ID1_AND_ID2_UP

Standard name SUH_COEXPRESSED_WITH_ID1_AND_ID2_UP
Systematic name M13616
Brief description Genes whose expression positively correlates with that of both ID1 and ID2 [GeneID=3397;3398] genes in a cohort of 285 patients with primaly AML (acule myelogenous leukemia) [PMID=15084694].
Full description or abstract Id1 is frequently overexpressed in many cancer cells, but the functional significance of these findings is not known. To determine if Id1 could contribute to the development of hematopoietic malignancy, we reconstituted mice with hematopoietic cells overexpressing Id1. We showed for the first time that deregulated expression of Id1 leads to a myeloproliferative disease in mice, and immortalizes myeloid progenitors in vitro. In human cells, we demonstrate that Id genes are expressed in human acute myelogenous leukemia cells, and that knock down of Id1 expression inhibits leukemic cell line growth, suggesting that Id1 is required for leukemic cell proliferation. These findings established a causal relationship between Id1 overexpression and hematologic malignancy. Thus, deregulated expression of Id1 may contribute to the initiation of myeloid malignancy, and Id1 may represent a potential therapeutic target for early stage intervention in the treatment of hematopoietic malignancy.Oncogene advance online publication, 9 June 2008; doi:10.1038/onc.2008.175.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 18542061   Authors: Suh HC,Leeanansaksiri W,Ji M,Klarmann KD,Renn K,Gooya J,Smith D,McNiece I,Lugthart S,Valk PJ,Delwel R,Keller JR
Exact source Table 3S: positively correlated
Related gene sets (show 36 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Jessica Robertson (MSigDB Team)
Source platform AFFY_HG_U133
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Version history 3.0: First introduced

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