Gene Set: TUOMISTO_TUMOR_SUPPRESSION_BY_COL13A1_UP

Standard name TUOMISTO_TUMOR_SUPPRESSION_BY_COL13A1_UP
Systematic name M1695
Brief description Genes up-regulated in small intestine tissue from transgenic mice expressing a mutant form of COL13A1 [GeneID=1305], compared to normal controls.
Full description or abstract Epithelial cells of mucosal surfaces are critical for maintaining immune homeostasis by aiding in the discrimination of pathogenic and commensal microorganisms and modulating the activities of antigen-presenting cells and lymphocytes. Functional breakdowns resulting in chronic infection and inflammation are associated with the development of hematologic and solid neoplasms for which detailed pathogenetic mechanisms are poorly understood. Mice heterozygous for a transgene Col13a1(del) expressing a mutant collagen XIII developed clonal mature B-cell lineage lymphomas originating in mesenteric lymph nodes (MLN). The tumors were associated with T cells and macrophages. The incidence of disease was reduced 2-fold in transgenic mice raised under specific pathogen-free conditions, suggesting a role for infectious agents. The lymphomas did not express the mutant collagen XIII, indicating that its influence on tumorigenesis was B-cell extrinsic and likely to be associated with collagen XIII-positive tissues drained by the MLN. Studies of the small intestines of transgenic mice showed that the subepithelial basement membranes (BM) were highly abnormal and that they exhibited heightened expression of genes involved in immune responses. These results define collagen XIII-dependent maintenance of the intestinal BM as a previously unappreciated component of immune responses and a critical determinant of cancer susceptibility.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 19074901   Authors: Tuomisto A,Sund M,Tahkola J,Latvanlehto A,Savolainen ER,Autio-Harmainen H,Liakka A,Sormunen R,Vuoristo J,West A,Lahesmaa R,Morse HC 3rd,Pihlajaniemi T
Exact source Table 1
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Organism Mus musculus
Contributed by Leona Saunders (MSigDB Team)
Source platform MOUSE_GENE_SYMBOL
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Version history 3.1: First introduced

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