Gene Set: UEDA_CENTRAL_CLOCK

Standard name UEDA_CENTRAL_CLOCK
Systematic name M2637
Brief description Molecular timetable composed of 96 time-indicating genes (103 probes) in the central (suprachiasmatic nucleus (SCN)) clock.
Full description or abstract Detection of individual body time (BT) via a single-time-point assay has been a longstanding unfulfilled dream in medicine, because BT information can be exploited to maximize potency and minimize toxicity during drug administration and thus will enable highly optimized medication. To achieve this dream, we created a molecular timetable composed of >100 time-indicating genes, whose gene expression levels can represent internal BT. Here we describe a robust method called the molecular-timetable method for BT detection from a single-time-point expression profile. The power of this method is demonstrated by the sensitive and accurate detection of BT and the sensitive diagnosis of rhythm disorders. These results demonstrate the feasibility of BT detection based on single-time-point sampling, suggest the potential for expression-based diagnosis of rhythm disorders, and may translate functional genomics into chronotherapy and personalized medicine.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15273285   Authors: Ueda HR,Chen W,Minami Y,Honma S,Honma K,Iino M,Hashimoto S
Exact source Table 2S
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Organism Mus musculus
Contributed by Kate Stafford (MSigDB Team)
Source platform AFFY_MG_U74
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Version history 3.0: Renamed from UEDA_MOUSE_SCN

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