Gene Set: UEDA_PERIFERAL_CLOCK

Standard name UEDA_PERIFERAL_CLOCK
Systematic name M12498
Brief description Molecular timetable composed of 162 time-indicating genes (182 probes) in the peripheral (liver) clock.
Full description or abstract Detection of individual body time (BT) via a single-time-point assay has been a longstanding unfulfilled dream in medicine, because BT information can be exploited to maximize potency and minimize toxicity during drug administration and thus will enable highly optimized medication. To achieve this dream, we created a molecular timetable composed of >100 time-indicating genes, whose gene expression levels can represent internal BT. Here we describe a robust method called the molecular-timetable method for BT detection from a single-time-point expression profile. The power of this method is demonstrated by the sensitive and accurate detection of BT and the sensitive diagnosis of rhythm disorders. These results demonstrate the feasibility of BT detection based on single-time-point sampling, suggest the potential for expression-based diagnosis of rhythm disorders, and may translate functional genomics into chronotherapy and personalized medicine.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15273285   Authors: Ueda HR,Chen W,Minami Y,Honma S,Honma K,Iino M,Hashimoto S
Exact source Table 1S
Related gene sets (show 1 additional gene sets from the source publication)

(show 45 gene sets from the same authors)
External links  
Filtered by similarity
Organism Mus musculus
Contributed by Kate Stafford (MSigDB Team)
Source platform AFFY_MG_U74
Dataset references  
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 170 genes
Gene families Categorize these 170 genes by gene family
Show members (show 182 members mapped to 170 genes)
Version history 3.0: Renamed from UEDA_MOUSE_LIVER

See MSigDB license terms here. Please note that certain gene sets have special access terms.