Gene Set: URS_ADIPOCYTE_DIFFERENTIATION_UP

Standard name URS_ADIPOCYTE_DIFFERENTIATION_UP
Systematic name M15476
Brief description Genes up-regulated in primary adipocytes compared to preadipocytes.
Full description or abstract Uncontrolled expansion of adipose tissue leads to obesity, a public health epidemic affecting >30% of adult Americans. Adipose mass increases in part through the recruitment and differentiation of an existing pool of preadipocytes (PA) into adipocytes (AD). Most studies investigating adipogenesis used primarily murine cell lines; much less is known about the relevant processes that occur in humans. Therefore, characterization of genes associated with adipocyte development is key to understanding the pathogenesis of obesity and developing treatments for this disorder. To address this issue, we performed large-scale analyses of human adipose gene expression using microarray technology. Differential gene expression between PA and AD was analyzed in 6 female patients using human cDNA microarray slides and data analyzed using the Stanford Microarray Database. Statistical analysis for the gene expression was performed using the SAS mixed models. Compared with PA, several genes involved in lipid metabolism were overexpressed in AD, including fatty acid binding protein, adipose differentiation-related protein, lipoprotein lipase, perilipin, and adipose most abundant transcript 1. Novel genes expressed in adipocytes included E2F5 transcriptional factor and SMARC (SWI/SNF-related, matrix associated, actin-dependent regulator of chromatin). PA predominantly expressed genes encoding extracellular matrix components such as fibronectin, matrix metalloprotein, and novel proteins such as lysyl oxidase. Despite the high differential expression of some of these genes, many did not differ significantly likely due to high variability and limited statistical power. A comprehensive list of differential gene expression is presented according to cellular function. In conclusion, these studies offer an overview of the gene expression profiles in PA and AD and identify new genes with potentially important functions in adipose tissue development and obesity that merit further investigation.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15051823   Authors: Urs S,Smith C,Campbell B,Saxton AM,Taylor J,Zhang B,Snoddy J,Jones Voy B,Moustaid-Moussa N
Exact source Table 1
Related gene sets (show 1 additional gene sets from the source publication)

(show 36 gene sets from the same authors)
External links  
Filtered by similarity
Organism Homo sapiens
Contributed by John Newman (University of Washington)
Source platform HUMAN_SEQ_ACCESSION
Dataset references  
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 66 genes
Gene families Categorize these 66 genes by gene family
Show members (show 76 members mapped to 66 genes)
Version history 3.0: Renamed from ADIP_HUMAN_UP

See MSigDB license terms here. Please note that certain gene sets have special access terms.