Systematic name M7854
Brief description Differentially expressed genes in a panel of xenografts representing 8 common pediatric tumors compared to the normal tissues.
Full description or abstract Human tumor xenografts have been used extensively for rapid screening of the efficacy of anticancer drugs for the past 35 years. The selection of appropriate xenograft models for drug testing has been largely empirical and has not incorporated a similarity to the tumor type of origin at the molecular level. This study is the first comprehensive analysis of the transcriptome of a large set of pediatric xenografts, which are currently used for preclinical drug testing. Suitable models representing the tumor type of origin were identified. It was found that the characteristic expression patterns of the primary tumors were maintained in the corresponding xenografts for the majority of samples. Because a prerequisite for developing rationally designed drugs is that the target is expressed at the protein level, we developed tissue arrays from these xenografts and corroborated that high mRNA levels yielded high protein levels for two tested genes. The web database and availability of tissue arrays will allow for the rapid confirmation of the expression of potential targets at both the mRNA and the protein level for molecularly targeted agents. The database will facilitate the identification of tumor markers predictive of response to tested agents as well as the discovery of new molecular targets.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 17210681   Authors: Whiteford CC,Bilke S,Greer BT,Chen Q,Braunschweig TA,Cenacchi N,Wei JS,Smith MA,Houghton P,Morton C,Reynolds CP,Lock R,Gorlick R,Khanna C,Thiele CJ,Takikita M,Catchpoole D,Hewitt SM,Khan J
Exact source Fig. 3A
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Organism Homo sapiens
Contributed by Jessica Robertson (MSigDB Team)
Source platform HUMAN_GENE_SYMBOL
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Version history 3.0: First introduced

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