Gene Set: YAGI_AML_SURVIVAL

Standard name YAGI_AML_SURVIVAL
Systematic name M18887
Brief description Genes differentially expressed in pediatric AML (acute myeloid leukemia) samples from patients with good survival (>3 years without relapse) compared to those with poor survival (relapsed within one year after treatment).
Full description or abstract Most patients with acute myeloid leukemia (AML) enter complete remission (CR) after treatment with chemotherapy, but a large number of them experience relapse with resistant disease. To identify genes that are associated with their prognoses, we analyzed gene expression in 54 pediatric patients with AML using an oligonucleotide microarray that contained 12 566 probe sets. A supervised approach using the Student t test selected a prognostic set of 35 genes, some of which are associated with the regulation of cell cycle and apoptosis. Most of these genes had not previously been reported to be associated with prognosis and were not correlated with morphologically classified French-American-British (FAB) subtypes or with karyotypes. These results indicate the existence of prognosis-associated genes that are independent of cell lineage and cytogenetic abnormalities, and they can provide therapeutic direction for individual risk-adapted therapy for pediatric AML patients.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 12738660   Authors: Yagi T,Morimoto A,Eguchi M,Hibi S,Sako M,Ishii E,Mizutani S,Imashuku S,Ohki M,Ichikawa H
Exact source Table 2S
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Organism Homo sapiens
Contributed by Kevin Vogelsang (MSigDB Team)
Source platform AFFY_HG_U95
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Version history 3.0: Renamed from YAGI_AML_PROG_ASSOC

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