Human Gene Set: YAO_HOXA10_TARGETS_VIA_PROGESTERONE_DN

For the Mouse gene set with the same name, see YAO_HOXA10_TARGETS_VIA_PROGESTERONE_DN

Standard name YAO_HOXA10_TARGETS_VIA_PROGESTERONE_DN
Systematic name M4435
Brief description Genes down-regulated in the uteri of ovariectomized mice 6 h after progesterone [PubChem=5994] injection: HOXA10 [GeneID=3206] knockout vs wild type animals.
Full description or abstract Human infertility and recurrent pregnancy loss caused by implantation defects are poorly understood. Hoxa-10-deficient female mice have severe infertility and recurrent pregnancy loss due to defective uterine implantation. Gene expression profiling experiments reveal that Hoxa-10 is an important regulator of two critical events in implantation: stromal cell proliferation and local immunosuppression. At the time of implantation, Hoxa-10 mediates the progesterone-stimulated proliferation of uterine stromal cells. Hoxa-10 mutants express a stromal cell proliferation defect that is accompanied by quantitative or spatial alterations in the expression of two cyclin-dependent kinase inhibitor genes, p57 and p15. Hoxa-10 deficiency also leads to a severe local immunological disturbance, characterized by a polyclonal proliferation of T cells, that occurs in place of the normal progesterone-mediated immunosuppression in the periimplantation uterus.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 12554760   Authors: Yao MW,Lim H,Schust DJ,Choe SE,Farago A,Ding Y,Michaud S,Church GM,Maas RL
Exact source Table 2
Related gene sets (show 19 additional gene sets from the source publication)

(show 8 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Kevin Vogelsang (MSigDB Team)
Source platform or
identifier namespace		 AFFY_MG_U74
Dataset references (show 2 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 20 genes
Gene families ? Categorize these 20 genes by gene family
Show members (show 27 source identifiers mapped to 20 genes)
Version history 3.0: Renamed from YAO_P4_KO_VS_WT_DN

See MSigDB license terms here. Please note that certain gene sets have special access terms.