Systematic name M17481
Brief description Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 7.
Full description or abstract Human infertility and recurrent pregnancy loss caused by implantation defects are poorly understood. Hoxa-10-deficient female mice have severe infertility and recurrent pregnancy loss due to defective uterine implantation. Gene expression profiling experiments reveal that Hoxa-10 is an important regulator of two critical events in implantation: stromal cell proliferation and local immunosuppression. At the time of implantation, Hoxa-10 mediates the progesterone-stimulated proliferation of uterine stromal cells. Hoxa-10 mutants express a stromal cell proliferation defect that is accompanied by quantitative or spatial alterations in the expression of two cyclin-dependent kinase inhibitor genes, p57 and p15. Hoxa-10 deficiency also leads to a severe local immunological disturbance, characterized by a polyclonal proliferation of T cells, that occurs in place of the normal progesterone-mediated immunosuppression in the periimplantation uterus.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 12554760   Authors: Yao MW,Lim H,Schust DJ,Choe SE,Farago A,Ding Y,Michaud S,Church GM,Maas RL
Exact source Supp. data: out_b_data Web S6: Cluster No.=7
Related gene sets (show 19 additional gene sets from the source publication)

(show 8 gene sets from the same authors)
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Organism Mus musculus
Contributed by Arthur Liberzon (MSigDB Team)
Source platform AFFY_MG_U74
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Version history 3.0: First introduced

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