Gene Set: YU_MYC_TARGETS_UP

Standard name YU_MYC_TARGETS_UP
Systematic name M1249
Brief description Genes up-regulated in B cell lymphoma tumors expressing an activated form of MYC [GeneID=4609].
Full description or abstract The involvement of the c-Myc transcription factor in neoplastic transformation is well documented. However, which of its numerous target genes are crucial for tumorigenesis remains a frequently contested issue. We have recently established a non-transgenic murine model for B-cell lymphoma based on neoplastic conversion of p53-null bone marrow cells by conditionally active Myc. Using this model, we have identified a number of genes whose expression levels are affected by Myc during B-lymphomagenesis. Here we discuss their possible roles in neoplastic processes and describe an experimental approach allowing in vivo validation of these roles. We demonstrate that lymphoma cells overexpressing one of the Myc targets, the interleukin-10 receptor gene, have a very strong selective advantage over low IL10R expressors. Furthermore, Mcl1, a presumptive IL10R effector, also confers selective advantages when overexpressed in Myc-transformed hematopoietic cells. Thus, both IL10R and Mcl1 might be amenable to therapeutic interventions, and new targets can be identified and validated using the selection approach.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 16382050   Authors: Yu D,Cozma D,Park A,Thomas-Tikhonenko A
Exact source Table 1
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Organism Mus musculus
Contributed by Kevin Vogelsang (MSigDB Team)
Source platform AFFY_MG_U74
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Version history 3.0: Renamed from YU_CMYC_UP

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