Standard name ZHU_CMV_ALL_UP
Systematic name M19630
Brief description Up-regulated at any timepoint following infection of primary human foreskin fibroblasts with CMV
Full description or abstract Mechanistic insights to viral replication and pathogenesis generally have come from the analysis of viral gene products, either by studying their biochemical activities and interactions individually or by creating mutant viruses and analyzing their phenotype. Now it is possible to identify and catalog the host cell genes whose mRNA levels change in response to a pathogen. We have used DNA array technology to monitor the level of approximately 6,600 human mRNAs in uninfected as compared with human cytomegalovirus-infected cells. The level of 258 mRNAs changed by a factor of 4 or more before the onset of viral DNA replication. Several of these mRNAs encode gene products that might play key roles in virus-induced pathogenesis, identifying them as intriguing targets for further study.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 9826724   Authors: Zhu H,Cong JP,Mamtora G,Gingeras T,Shenk T
Exact source Table 1: U
Related gene sets (show 5 additional gene sets from the source publication)

(show 29 gene sets from the same authors)
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Organism Homo sapiens
Contributed by John Newman (University of Washington)
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Version history 3.0: Renamed from CMV_ALL_UP

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