PTMsigDB collection: Post-Translational Modification Signatures

Note: The PTMsigDB sets are not for use with regular GSEA.

The PTM signatures database is a collection of modification site-specific signatures of perturbations, kinase activities and signaling pathways curated from literature. PTMsigDB provides the foundation for site-specific PTM-signature enrichment analysis of mass spectrometry derived PTM datasets. See Krug et al. 2019 for details about the curation process of PTMsigDB and PTM-SEA methodology.

The PTMsigDB database can be found at https://proteogenomics.shinyapps.io/ptmsigdb.
The source code and information about the PTM-SEA method can be found at https://github.com/broadinstitute/ssGSEA2.0.

Note: Despite the name of the GitHub repository the PTM-SEA method is not an updated 2.0 replacement of the ssGSEA method, but rather an adaptation of the method for proteomics.

PTMsigDB and PTM-SEA are developed by the Proteomics group at the Broad Institute. If you have questions or need help, please contact them through the group's contact page or by creating an issue in their GitHub repository.