PTMsigDB collection: Post-Translational Modification Signatures

The PTM signatures database (PTMsigDB)  is a collection of modification site-specific signatures of perturbations, kinase activities and signaling pathways curated from literature. PTMsigDB provides the foundation for site-specific PTM-signature enrichment analysis (PTM-SEA) of mass spectrometry derived PTM datasets. See Krug et al. 2019 for details about the curation process of PTMsigDB and PTM-SEA methodology.

PTMsigDB and PTM-SEA are developed by the Proteomics group at the Broad Institute.

Note: The PTMsigDB sets are not for use with regular GSEA.